Assessment of matrix effect of tomato and okra on the quantification of pesticides residues using UHPLC–MS/MS

Liquid chromatography coupled with tandem mass-spectrometry has remarkably enhanced the qualitative and quantitative analysis of pesticide residues in agriculture matrices. The matrix effects may either suppress or enhance responses target analytes on UPLC-MS/MS cause a reduction accuracy, precision sensitivity an analytical method. Thus, Here performed impact interferences tomato okra QuEChERS based multi-residue quantification UHPLC-MS/MS by comparing calibration curves matrix-matched pure solvent-based standards 116 pesticides. Signal suppression was more pronounced where >76% pesticides recorded ME% values >50% while case 91% shown negligible effect. Careful consideration effect particularly like difficult matrices, before analysing real sample will help chemist to avoid over under estimation toxic UHPLC–MS/MS highly sensitive techniques.